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cyclic AMP
cyclic AMP
Compartmentalized phosphodiesterase-2 activity blunts β-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway
Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol
Mutagenesis of important amino acid reveals unconventional homologous internalization of β1-adrenergic receptor
Life Sciences / Western blotting / Internalization / Cell line / Humans / Mutation / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol / Cell Membrane / Mutation / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol / Cell Membrane
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
Molecular Evolution / Cyanobacteria / Biological Chemistry / Western blotting / Biological Sciences / DNA / Phylogeny / Xenopus / Mutation / cyclic AMP / Animals / Biological / Alternative splicing / Dictyostelium / CHEMICAL SCIENCES / Introns / Molecular cloning / Time Factors / Plasmodium falciparum / Xenopus laevis / Alternative Splicing / Amino Acid Sequence / Base Sequence / Oocytes / Molecular Sequence Data / DNA / Phylogeny / Xenopus / Mutation / cyclic AMP / Animals / Biological / Alternative splicing / Dictyostelium / CHEMICAL SCIENCES / Introns / Molecular cloning / Time Factors / Plasmodium falciparum / Xenopus laevis / Alternative Splicing / Amino Acid Sequence / Base Sequence / Oocytes / Molecular Sequence Data
Neutral trehalases catalyse intracellular trehalose breakdown in the filamentous fungi Aspergillus nidulans and Neurospora crassa
Carbon / Calcium / Molecular Microbiology / Genetic Engineering / Neurospora crassa / Biological Sciences / Molecular / Mutation / cyclic AMP / Trehalose / Aspergillus Nidulans / Filamentous fungi / Amino Acid Sequence / Molecular Sequence Data / Biological Sciences / Molecular / Mutation / cyclic AMP / Trehalose / Aspergillus Nidulans / Filamentous fungi / Amino Acid Sequence / Molecular Sequence Data
Developmental Changes in Prostaglandin E2 Receptor Subtypes in Porcine Ductus Arteriosus Possible Contribution in Altered Responsiveness to Prostaglandin E2
Kinetics / Signal Transduction / Permeability / cyclic AMP / Animals / Clinical Sciences / Public health systems and services research / Swine / Radioligand Assay / Tritium / Circulation / Congenital Heart Disease / Gestational Age / Ductus Arteriosus / Prostaglandin E2 / Clinical Sciences / Public health systems and services research / Swine / Radioligand Assay / Tritium / Circulation / Congenital Heart Disease / Gestational Age / Ductus Arteriosus / Prostaglandin E2
In Central Obesity, Weight Loss Restores Platelet Sensitivity to Nitric Oxide and Prostacyclin
Obesity / Multidisciplinary / Insulin Resistance / Adipose tissue / Humans / Platelet aggregation / Weight Loss / cyclic AMP / Nitric oxide / Female / Male / Vascular endothelium / Endothelial dysfunction / Platelet activation mechanism / Platelet function / Adult / Central Obesity / Cyclic nucleotides / Body Weight / cyclic GMP / Adenosine Diphosphate / Sodium Nitroprusside / Platelet aggregation / Weight Loss / cyclic AMP / Nitric oxide / Female / Male / Vascular endothelium / Endothelial dysfunction / Platelet activation mechanism / Platelet function / Adult / Central Obesity / Cyclic nucleotides / Body Weight / cyclic GMP / Adenosine Diphosphate / Sodium Nitroprusside
Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists
Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension
Neuroscience / Enzyme Inhibitors / Molecular Mechanics / cyclic AMP / Animals / Spinal Cord / P-glycoprotein / Axon Guidance / The / Rats / Exocytosis / Cell Surface Markers / Axons / Plasma Membrane / Protein Transport / Cell Adhesion Molecules / Axon Outgrowth / Spinal Cord / P-glycoprotein / Axon Guidance / The / Rats / Exocytosis / Cell Surface Markers / Axons / Plasma Membrane / Protein Transport / Cell Adhesion Molecules / Axon Outgrowth
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension
Neuroscience / Enzyme Inhibitors / Molecular Mechanics / cyclic AMP / Animals / Spinal Cord / P-glycoprotein / Axon Guidance / The / Rats / Exocytosis / Cell Surface Markers / Axons / Plasma Membrane / Protein Transport / Cell Adhesion Molecules / Axon Outgrowth / Spinal Cord / P-glycoprotein / Axon Guidance / The / Rats / Exocytosis / Cell Surface Markers / Axons / Plasma Membrane / Protein Transport / Cell Adhesion Molecules / Axon Outgrowth
P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport
Immunohistochemistry / Xenopus / Video microscopy / cyclic AMP / Animals / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate
cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons
Calcium / Biological Chemistry / Biological Sciences / cyclic AMP / Animals / Biological / Phosphorylation / Neurons / CHEMICAL SCIENCES / Rats / Intracellular Calcium / Biological / Phosphorylation / Neurons / CHEMICAL SCIENCES / Rats / Intracellular Calcium
Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists
Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma
Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma
Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma
Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma
Mutagenesis of important amino acid reveals unconventional homologous internalization of β1-adrenergic receptor
Life Sciences / Western blotting / Cell line / Humans / Mutation / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol
Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels
Cystic Fibrosis / Immunohistochemistry / Gene expression / Cell line / Humans / cyclic AMP / Cellular Physiology / Medical Physiology / Gene Dosage / Phenotype / mRna expression levels / Epithelial cells / Bronchial Epithelial Cells / Ion Transport / Transgene Expression / Electric Conductivity / Plasma Membrane / Full Length Movies / Gene Expression Regulation / Chlorides / cyclic AMP / Cellular Physiology / Medical Physiology / Gene Dosage / Phenotype / mRna expression levels / Epithelial cells / Bronchial Epithelial Cells / Ion Transport / Transgene Expression / Electric Conductivity / Plasma Membrane / Full Length Movies / Gene Expression Regulation / Chlorides
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